Overview
Combinatorial Chemistry is a “State-of-the-art” technology which facilitates the rapid synthesis of organic molecules with a wide range of structural diversity. This, when coupled with the natural product libraries and high throughput screening, will accelerate new drug discoveries and utilization of the vast natural biodiversity of India for value added products
Mission
& Goals
- Compound libraries for lead discovery
- Medicinal plant processing based on activity
- Bio-assays for high throughput screening
- New targets for HTS assay developments
- New molecular scaffolds for specific diseases
Competencies
- Chemical synthesis of combinatorial libraries
- Bio-evaluation of medicinal plants
- Biological high throughput screening
- Chemoinformatics
Facilities
High throughput screening system (Biomek 2000)
Accelerated solvent extractor (Dionex ASE 300)
HT evaporation system (Genevac HT 12)
- SEPBOX (SepiatecCSEP-C9116) Simulated moving bed chromatography system (Knaur)
Organic parallel synthesizer (ASW 2000P)
- Isothermal titration calorimeter (Microcal VP-ITC)
Glimpses
of current research
- Synthesis and evaluation of libraries for anti-inflammatory activity
- Natural product derived new lead molecules for antidepressant activity.
Contact
Dr. KN Ganesh
National Chemical Laboratory ,
Pune 411 008
Email
:kng@ems.ncl.res.in
Phone
:+91-20-2589 3300/2589 3153
Fax
:+91-20-2589 3153
Dr. AA Natu
National Chemical Laboratory ,
Pune 411 008
Email
:aan@ems.ncl.res.in
Phone
:+91-20-2589 3153
Fax
:+91-20-2589 3153
Dr. MK Gurjar
National Chemical Laboratory ,
Pune 411 008
Email
:gurjar@dalton.ncl.res.in
Phone
:+91-20-25893543, 2588 2456
Fax
:+91-20-2589 3614